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However, epidemiological data suggest that one case of NAION might be expected in a cohort of 8893 sildenafil users [5]. The mechanism by which this medication might damage the optic nerve is not well understood. One hypothesis is vascular insufficiency at the optic nerve head. This insufficiency and the resulting ischemia may be more frequent in people with certain anatomical characteristics (for example, small physiological cup) [6] viagra hard bigg. It has been theorized that sildenafil, which works through the nitric oxide-cyclic GMP pathway, may alter the perfusion of the optic nerve head by modifying nitric oxide levels [4]. In fact, the drug increases nitric oxide levels, which in turn cause reduced perfusion [4]. Sildenafil also has a weaker inhibitory action on PDE6, located in the rod and cone photoreceptors. This could explain the modest, transient visual symptoms, as well as typically blue tinge to vision, increased brightness discount coupons for viagra 100mg from pfizer lights and blurry vision, reported with sildenafil use, and occurring more frequently at higher doses [1].

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To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here. Viagra (sildenafil) Disease Interactions. There are 9 disease interactions with Viagra (sildenafil): Pde5 Inhibitors (Includes Viagra) 8596; Cardiovascular Disease. Severe Potential Hazard, High plausibility. Applies to: Cardiovascular Disease, Hypotension, History - Cerebrovascular Disease, Cerebral Vascular Disorder, History - Myocardial Infarction.

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