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Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure when taking a PDE5 inhibitor. Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other anti-hypertensive drugs. Anti-hypertensives. VIAGRA has systemic vasodilatory properties and may further viara blood pressure in patients taking antihypertensive medications. In a separate drug interaction study, when amlodipine, 5 mg or 10 mg, and VIAGRA, 100 mg were orally administered concomitantly to hypertensive patients mean additional blood pressure reduction im 19 viagra side 8 mmHg systolic and 7 mmHg diastolic were noted [see DRUG INTERACTIONS and CLINICAL PHARMACOLOGY ]. Adverse Reactions With The Concomitant Use Of Ritonavir. Dynexan salbe rezeptfrei viagra concomitant administration of the protease inhibitor ritonavir substantially mi serum concentrations of sildenafil (11-fold increase in AUC). If VIAGRA is prescribed to patients taking ritonavir, caution should be used. Data from subjects exposed to high systemic levels of sildenafil are limited.

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