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Product Description

Mechanism Of Action. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates plantillas para pie plano donde comprar viagra enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on viagar human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation. Binding Characteristics. Studies in vitro have shown canada prescription viagra sildenafil is selective for PDE5.

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Detailed information

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Relaxed muscles allow blood to flow freely so that when youâre aroused, you can get an erection. It also helps you maintain the erection long enough to have sex. Levitra and Viagra stay in your bloodstream for about four to six hours.

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