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The research team at the Albert Einstein College of Medicine at Yeshiva University, in New York, used nanoparticles, each much smaller than a grain of pollen, and found a way to encapsulate particles of the drug inside. Their early tests involved just a few rats bred to have erectile dysfunction later in life. Of these, 11 were treated with nanoparticles containing Cialis, a newer erectile dysfunction drug called sialorphin, and nitric oxide, a chemical also needed to widen blood vessels and produce an erection, often reduced in men with diabetes.

Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking Viagra with a nitrate medicine can cause a sudden and serious decrease in blood pressure. To make sure Viagra is safe for you, tell your doctor if you have ever had: heart disease or heart rhythm problems, coronary artery disease; a heart attack, stroke, or congestive heart failure; high or low blood pressure; liver or kidney disease; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a bleeding disorder such as hemophilia; a stomach ulcer; retinitis pigmentosa (an inherited condition of the eye); a physical deformity of the penis (such as Peyronie's disease); or. if you have been told you should not have sexual intercourse for health reasons.]