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However, a 2017 report from the Testosterone Trials noted that testosterone therapy can raise the risk of heart disease and stroke, and may not be safe is men with low-but-normal testosterone levels and no outward symptoms related to low T. Overall, the Testosterone Trials showed that the volume of arterial plaque increased more in the testosterone-treated group compared to the untreated "control" group, which could increase the risk over time for heart attack or stroke. The trials showed a positive benefit for bone health and anemia, but experts stated that it's unlikley testosterone will be considered a first-line treatment for those conditions, as other more effective and well-established options are available.

As Nobel Prize-winning economist Gary Becker of the University of Chicago put it in a recent blog entry: "Many of those who receive higher wages are not poor but are teenagers and other secondary workers in middle-class and rather rich families.]