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saquinavir, ketoconazole, itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of sildenafil [see DOSAGE AND ADMINISTRATION ]. In vivo Studies. Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56 increase in plasma sildenafil concentrations when co-administered with VIAGRA (50 mg) to healthy volunteers. When a single 100 mg dose of VIAGRA was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 160 increase in sildenafil Cmax and a 182 increase in sildenafil AUC. In addition, in a study performed in healthy male volunteers, co-administration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with Viagra (100 mg single dose) resulted in a 140 increase in sildenafil Cmax and a 210 increase in sildenafil AUC. Viagra had no effect on saquinavir pharmacokinetics.

Posted 20 Nov 2010 bull; 2 answers.]