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Here we show that augmentation of nitric oxide-cyclic guanosine monophosphate signaling by short-term daily administration of the phosphodiesterase 5 inhibitor sildenafil increases protein synthesis, alters protein expression and nitrosylation, and reduces fatigue in human skeletal muscle. These findings suggest that phosphodiesterase 5 inhibitors represent viable pharmacologic interventions to improve muscle function. About Will Brink.

" Int J Clin Pract 52 (1998): 375-9. Gilad R, Lampl Y, Eshel Y, Sadeh M "Tonic-clonic seizures in patients taking sildenafil. " BMJ 325 (2002): 869. Savitz SA, Caplan LR "Transient global amnesia after sildenafil (Viagra) use. " Neurology 59 (2002): 778. Vobig MA, Klotz T, Staak M, BartzSchmidt KU, Engelmann U, Walter P "Retinal side-effects of sildenafil.

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